Drug materials restrict the development of drug release syst

With the progress of science, the research of drug preparation has entered into the era of drug release system. Future drug delivery systems will play a pivotal role in the field of pharmaceutical, biotechnology and biological therapy. The development of drug materials has become an important factor restricting the development of drug release system in China. Some experts suggest that we should pay attention to the role of medicinal materials in the preparation of research, increase support efforts to promote the rapid and healthy development of domestic accessories industry.

Due to the drug delivery system of drug release function completely by materials to support, so a re evaluation of the new materials research and application, the existing functional excipients and preparation process study should become the preferred research projects in pharmaceutical enterprises in our country. China Senior pharmaceutical experts Shen Hui Feng researcher believes that the active drug in pharmaceutical dosage form is substantial part, determines the role of the direction; accessories to ensure drug to certain program selectively delivered to tissues, prevent the drug from the body release before inactivation, and the drug in vivo according to a certain speed and time, in certain parts of the release. Therefore, it is a key role to play a positive role in the practical application of the drug and the effect of the drug.

In recent years, the role of medicinal materials in drug release system is increasing, and its application is very extensive. Such as design and manufacturing of oral sustained / controlled release drug delivery system main application of polymer materials, such as ethyl cellulose, light propyl methyl cellulose, polypropylene acid tree vinegar series, de acetylation of chitosan and glycoprotein is also applied, inclusion of controlled release applications are increasing. For example, microcapsules and particle type controlled-release preparation commonly used gelatin, starch, albumin, polylactic acid, poly lactic acid copolymer, a light acid poly methyl amine, ethyl cellulose, polypropylene based Cool polymer; biodegradable polymer (copolymer of polylactic acid, polyglycolic acid and polyglycolic acid lactic acid) used for protein and peptide drugs delivery can reduce dosage, increase the protein stability and achieve positioning, constant release; Dextran and chitosan can be decomposed in colonic bacterial enzymes, and in the stomach and the small intestine is not easy solution, ocstds suitable carrier for most materials; colon targeted drug delivery system to adhesion is non specific carrier, such as alginate, cellulose derivatives, dextran, gelatin, pectin and chitosan, the application of carbomer Extensive; methyl acrylic acid copolymer, light propyl methyl cellulose acetate glassy shoot acid cool, adjacent benzene dicarboxylic acid cellulose acetate were used as enteric coating material; cyclodextrin in the colonic microbial fermentation is decomposed into oligosaccharides, but not easy to be hydrolyzed and therefore not in the stomach and small intestine in drug release, for preparation of colon targeted drug delivery system.

"China's pharmaceutical industry has long been the development of heavy raw materials, light preparation research. China's drug release technology in general compared with the world's advanced level there is still a large gap between the slow controlled release preparation, for example, there are more than 200 foreign countries, China's normal production is less than 100." China Medicine University School of medicine, Professor Tu Jiasheng pointed out that China's drug delivery system is mainly to trace the study, the development and application of new drug release technology is not a lot. There are many reasons for the lag of development, but the cause of the auxiliary materials can not be ignored. In Chinese medicine to the development of drug delivery system for, in addition to the traditional Chinese medicine composition is complicated, is difficult to determine the material basis for efficacy; traditional Chinese medicine preparation technology is relatively backward, science and technology content is not high, weak competitiveness, low added value; the compound preparation study, there are still some difficulties and other factors, new accessories untapped applications to are also important factors in a traditional Chinese medicine preparation. At present, although there are more than ten kinds of new medicinal materials used in traditional Chinese medicine preparation, but the real use of more only cyclodextrin, shuttle, methyl cellulose, sodium, etc..

Tu Jia Sheng believes that now there are a considerable part of the quality of the materials in the country is not stable, it is not up to the requirements of drug release technology. So there is little of the slow release of controlled release drug part of the drug can only stay in the laboratory, unable to carry out large-scale production, it is difficult to enter the market. In addition, our country in the new supplementary materials research and development of medicinal materials and other aspects of quality control is also far behind the developed countries. He suggested that the relevant departments of the state should actively organize, research units and enterprises in close cooperation, scientific planning, unified management, to strengthen the quality of medicinal materials to improve research. Should focus on the development of a variety of formulations with related accessories, such as the new adhesive, disintegration agent, coating materials, pigments, solvents, surfactants, etc.. Strengthen the phospholipids with beans on cellulose derivatives, injection of enteric coated materials developed by Poirot, Sharm hatch phosphatide and injection. In addition, through policy incentives and other means to accelerate the rapid and healthy development of China's accessories industry.